JOURNAL ARTICLE

Anti-cancer effects of plant-derived Micromonospora sp. M2 against A549 and MCF-7 cell lines.

  • Published In: Bioscience, Biotechnology & Biochemistry, 2024, v. 88, n. 6. P. 608 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Jeong, Gyeong Han; Bak, Dong-Ho; Lee, Hanui; Cho, Ja Young; Kang, Seong Hee; Chung, Byung Yeoup; Park, Sanghwa; Bai, Hyoung-Woo 3 of 3

Abstract

This article focuses on the anticancer potential of an extract from Micromonospora sp. M2 (MBE), a bacterial strain isolated from the root of Monochoria korsakowii in Korea. The study demonstrates that MBE inhibits proliferation and colony formation in human lung carcinoma (A549) and breast adenocarcinoma (MCF7) cell lines by inducing apoptotic cell death through increased intracellular reactive oxygen species (ROS), suppression of the PI3K-AKT pathway, and activation of the JNK/P38 mitogen-activated protein kinase (MAPK) pathway. Major bioactive components identified in MBE include polyketide derivatives lobosamides A, C, and D. The findings suggest MBE's potential as a selective anticancer agent, warranting further isolation, characterization, and in vivo evaluation before clinical application.

Additional Information

  • Source:Bioscience, Biotechnology & Biochemistry. 2024/06, Vol. 88, Issue 6, p608
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0916-8451
  • DOI:10.1093/bbb/zbae036
  • Accession Number:177375214
  • Copyright Statement:Copyright of Bioscience, Biotechnology & Biochemistry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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