JOURNAL ARTICLE

Serum Zonulin Level in Patients with Bipolar Disorder.

  • Published In: QJM: An International Journal of Medicine, 2024, v. 117. P. ii217 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Thabet, Dina Mohamed; Abd EL Aziz, Mohamed Fekry; Hashem, Nivert Zaki; Moneim Mahmoud, Dalia Abdel 3 of 3

Abstract

The article focuses on a study assessing serum zonulin levels, a biomarker of intestinal permeability, in patients with bipolar disorder I in Egypt. The study involved 200 bipolar I patients—100 in acute manic or depressive episodes and 100 in remission—compared to 100 healthy controls, finding significantly higher zonulin levels in patients, especially during acute episodes. These results suggest a potential role of increased intestinal permeability or blood-brain barrier dysfunction in the pathogenesis of bipolar disorder. The research highlights the gut-brain axis as an important area for understanding immune-related mechanisms in bipolar disorder.

Additional Information

  • Source:QJM: An International Journal of Medicine. 2024/10, Vol. 117, pii217
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1460-2725
  • DOI:10.1093/qjmed/hcae175.506
  • Accession Number:181636125
  • Copyright Statement:Copyright of QJM: An International Journal of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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