JOURNAL ARTICLE

Laser Interstitial Thermal Therapy for the Treatment of Mesial Temporal Lobe Epilepsy in Children.

  • Published In: Journal of Child Neurology, 2025, v. 40, n. 5. P. 342 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Trivedi, Aditi M.; Montenegro, Maria A.; Gonda, David; Kim-McManus, Olivia; Rismanchi, Neggy; Frederick, Aliya; Guido-Estrada, Natalie; Jindal, Anuja; Sattar, Shifteh 3 of 3

Abstract

This article evaluates the efficacy of laser interstitial thermal therapy (LITT) in treating drug-resistant mesial temporal lobe epilepsy (MTLE) in children and adolescents. In a retrospective cohort study of 19 patients at a level 4 epilepsy center, 73.5% achieved seizure freedom (Engel 1 outcome) at 12 months post-surgery, with higher rates in patients showing hippocampal sclerosis on MRI (90%) compared to those with normal MRI findings (55.5%). Younger age at seizure onset predicted better surgical outcomes, while no significant complications were reported, supporting LITT as a safe and effective minimally invasive alternative to open surgery for pediatric MTLE. The study highlights the need for further prospective research to clarify factors influencing seizure freedom, including ablation volume and genetic influences.

Additional Information

  • Source:Journal of Child Neurology. 2025/05, Vol. 40, Issue 5, p342
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0883-0738
  • DOI:10.1177/08830738241312262
  • Accession Number:184528903
  • Copyright Statement:Copyright of Journal of Child Neurology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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