JOURNAL ARTICLE

Investigation of polyvinylpyrrolidone-catechol-derived chitosan nanoconjugates allowed for kidney-targeted treatment of cisplatin-induced acute kidney injury and nursing care management.

  • Published In: Journal of Biomaterials Applications, 2025, v. 39, n. 9. P. 1084 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Chen, Guixian 3 of 3

Abstract

This article focuses on the development and evaluation of polyvinylpyrrolidone-catechol-derived chitosan nanoconjugates (PCChi-NC) as a targeted therapeutic approach for cisplatin (Cs)-induced acute kidney injury (AKI). Characterization confirmed the nanoconjugates’ size (20–60 nm) and stability, while in vitro and in vivo studies demonstrated their biocompatibility and kidney-specific accumulation. PCChi-NC treatment reduced Cs-induced cytotoxicity, apoptosis, oxidative stress, and inflammation in kidney cells and mouse models, as evidenced by improved biomarkers and histopathological outcomes. These findings suggest that PCChi-NC offers a promising strategy for mitigating nephrotoxicity associated with cisplatin chemotherapy through enhanced renal targeting and protective effects.

Additional Information

  • Source:Journal of Biomaterials Applications. 2025/04, Vol. 39, Issue 9, p1084
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0885-3282
  • DOI:10.1177/08853282241304396
  • Accession Number:183433758
  • Copyright Statement:Copyright of Journal of Biomaterials Applications is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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