JOURNAL ARTICLE

Utilizing plasma drug levels and genetic testing to achieve optimal treatment response in a patient with treatment‐resistant schizoaffective disorder.

  • Published In: Bipolar Disorders, 2024, v. 26, n. 1. P. 95 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Xu, Jin‐jie; Xiao, Chunfeng; Pan, Yanli; Tang, Yi‐lang; Wang, Mingwan; Li, Sheng; Xie, Gaoming; Du, Jing; Ren, Yanping; Wang, Wei 3 of 3

Abstract

We report the case of a Chinese male with schizoaffective disorder, an active smoker and a nonresponder to clozapine (600 mg daily). Therapeutic clozapine monitoring was analyzed, revealing a low concentration‐dose ratio. A pharmacogenetic test showed that the patient had the CYP1A2*1F/*1F genotype, indicating an ultra‐rapid clozapine metabolizer. In combination with fluvoxamine, a CYP1A2 enzyme inhibitor, clozapine plasma concentrations approached the reference range and achieved clinical improvement. This case demonstrates how pharmacogenetics can help understand the value of therapeutic drug monitoring to enhance the treatment of refractory schizoaffective disorder. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Bipolar Disorders. 2024/02, Vol. 26, Issue 1, p95
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1398-5647
  • DOI:10.1111/bdi.13385
  • Accession Number:175365117
  • Copyright Statement:Copyright of Bipolar Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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