JOURNAL ARTICLE

P10 Think zinc: nutritional deficiency in a breastfed infant associated with antenatal proton-pump inhibitor exposure.

  • Published In: British Journal of Dermatology, 2023, v. 189, n. 3. P. e46 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Porter, Emma; Molloy, Oonagh; Murphy, Michelle; O'Connor, Cathal 3 of 3

Abstract

This article focuses on a case of zinc deficiency in a 5-month-old breastfed infant presenting with dermatitis and recurrent infections, linked to maternal use of proton-pump inhibitors (PPIs) during late pregnancy. The infant exhibited low serum zinc levels and improved rapidly with zinc supplementation, while maternal breastmilk zinc was also low despite normal maternal serum zinc. Genetic testing ruled out inherited zinc transporter defects, and the report suggests that maternal PPI use may impair transplacental or transmammary zinc transfer. This case is noted as the first reported instance associating maternal PPI use with zinc deficiency in a breastfed infant.

Additional Information

  • Source:British Journal of Dermatology. 2023/09, Vol. 189, Issue 3, pe46
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0007-0963
  • DOI:10.1093/bjd/ljad259.020
  • Accession Number:172425508
  • Copyright Statement:Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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