JOURNAL ARTICLE

Super-enhancer-driven ameboidal-type cell migration-related MMP14 expression in tongue squamous cell carcinoma switched by BATF and ATF3.

  • Published In: Journal of Pharmacy & Pharmacology, 2025, v. 77, n. 1. P. 64 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shi, Zhimin; Wang, Rui; Huang, Jie; Qian, Qian; Hu, Menglin; Zhang, Hengguo; Feng, Linfei; Gu, Hao; Wang, Yuanyin 3 of 3

Abstract

This article focuses on the role of super-enhancers (SEs) and related transcription factors in regulating metastasis in tongue squamous cell carcinoma (TSCC). The study identifies that SE-associated genes are enriched in ameboidal-type cell migration pathways, with the matrix metalloproteinase gene MMP14 (encoding MT1-MMP) being a key target. Transcription factors BATF and ATF3 were found to antagonistically regulate MMP14 expression by switching interactions with SE regions, influencing TSCC cell migration and patient survival outcomes. These findings suggest that SEs and their regulatory networks may serve as potential therapeutic targets for controlling TSCC metastasis.

Additional Information

  • Source:Journal of Pharmacy & Pharmacology. 2025/01, Vol. 77, Issue 1, p64
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0022-3573
  • DOI:10.1093/jpp/rgae063
  • Accession Number:182369949
  • Copyright Statement:Copyright of Journal of Pharmacy & Pharmacology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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