JOURNAL ARTICLE

BRCA1/BRCA2 Germline Gene Mutations in Breast Cancer Egyptian Female Patients.

  • Published In: QJM: An International Journal of Medicine, 2024, v. 117. P. ii83 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Elsayed, Sally; Talkhan, Hala Ahmed; Mamdouh, Rasha; Elkady, Mohamed Sabry; Elkabarity, Rania Hamdy; Wahba, Nancy Samir 3 of 3

Abstract

The article focuses on two main studies related to medical diagnostics in Egypt. The first study evaluates serum eosinophil-derived neurotoxin (EDN) as a biomarker for eosinophilic inflammation in pediatric patients with bronchial asthma and preschool wheezes, finding significantly elevated EDN levels correlated with eosinophilia and type 2 airway inflammation. The second study investigates the prevalence of germline BRCA1 and BRCA2 gene mutations among Egyptian female breast cancer patients, reporting no detected mutations in the examined cohort. These findings highlight EDN’s potential utility in asthma screening and suggest a low prevalence of common BRCA1/2 mutations in the studied Egyptian breast cancer population.

Additional Information

  • Source:QJM: An International Journal of Medicine. 2024/10, Vol. 117, pii83
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1460-2725
  • DOI:10.1093/qjmed/hcae175.192
  • Accession Number:181635812
  • Copyright Statement:Copyright of QJM: An International Journal of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.