JOURNAL ARTICLE

Studies from University of Ibadan Yield New Data on Neurodegeneration (Monosodium glutamate aggravates social defeat stress-induced behavioral dysfunctions by promoting neurodegeneration and downregulating prefrontal cortex BDNF expressions in...).

Published In: Mental Health Weekly Digest, 2025. P. 1852 1 of 2
Database: Psychology Source 2 of 2

Abstract

The article focuses on research examining the effects of monosodium glutamate (MSG) on neurodegeneration and behavioral dysfunctions induced by social defeat stress (SDS) in mice. Conducted by researchers at the University of Ibadan, the study found that MSG exacerbated depression and anxiety-like behaviors, impaired social interactions, and increased blood glucose and corticosterone levels in mice subjected to SDS. Additionally, high doses of MSG were linked to increased neuronal degeneration in the hippocampus and prefrontal cortex, along with decreased brain-derived neurotrophic factor (BDNF) expression in these regions. The findings suggest that MSG may worsen mental health risks associated with stress by disrupting neuronal integrity. [Extracted from the article]

Additional Information

Source:Mental Health Weekly Digest. 2025/09, p1852
Document Type:Article
Subject Area:Health and Medicine
Publication Date:2025
ISSN:1543-6616
Accession Number:187925918
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