Improved psychosexual wellbeing with administration of combined Sildenafil plus Melatonin compared than either drug alone in management of women with polycystic ovarian syndrome: a 3-month randomized clinical study.

This article focuses on a randomized clinical trial assessing the effects of adjunctive Sildenafil plus Melatonin on psycho-sexual status in Iranian women with Polycystic Ovarian Syndrome (PCOS) undergoing Metformin treatment. The study found that a 12-week combined administration of Sildenafil and Melatonin significantly improved menstrual cyclicity, sexual function (notably desire and arousal), depression severity, and health-related quality of life (HRQOL) related to menstrual and emotional domains compared to Metformin alone or either drug separately. While clinical and biochemical markers showed no significant changes, the combined treatment demonstrated superior benefits on psychological and sexual health outcomes. Limitations include the study’s single-center design, inclusion of only married women due to cultural norms, and lack of post-intervention follow-up to assess the durability of effects.