JOURNAL ARTICLE

"methods, Systems And Compositions for Inhibition of Cellular Dysfunction And Cell Death with Deuterated PUFAs" in Patent Application Approval Process (uspto 20230165824).

  • Published In: Mental Health Weekly Digest, 2023. P. 2029 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

Keywords: Brain Diseases and Conditions; Central Nervous System Diseases and Conditions; Cytoskeletal Proteins; Dementia; Disease Attributes; Disease Progression; Enzymes and Coenzymes; Genetics; Health and Medicine; Mental Health; Microtubule-Associated Proteins; Nervous System Diseases and Conditions; Neurodegenerative Diseases and Conditions; Patent Application; Tauopathies; tau Proteins EN Brain Diseases and Conditions Central Nervous System Diseases and Conditions Cytoskeletal Proteins Dementia Disease Attributes Disease Progression Enzymes and Coenzymes Genetics Health and Medicine Mental Health Microtubule-Associated Proteins Nervous System Diseases and Conditions Neurodegenerative Diseases and Conditions Patent Application Tauopathies tau Proteins 2029 2029 1 06/19/23 20230623 NES 230623 2023 JUN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- A patent application by the inventors Milner, Peter (Los Altos, CA, US); Schepinov, Mikhail Sergeevich (Oxford, GB), filed on September 2, 2022, was made available online on June 1, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. "Without being limited to any theory, those neurons containing sufficient deuterated arachidonic acid with a sufficiently long half-life to resist oxidation at the bis-allylic sites of deuterated arachidonic acid by reactive oxygen species (ROS) as compared to wild type arachidonic acid. As more cells die, the affected portion of the brain shrinks; and "late onset Tay-Sachs is a very rare genetic neurodegenerative disease in which fatty compounds, called gangliosides, do not break down fully because the body produces too little of the enzyme hexosaminidase A (or hex A). The deuterated arachidonic acid accumulates over time into at-risk neurons of a patient until these cells are able to maintain the concentration of 15-HpETE-PE below that which triggers the death signal. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2023/06, p2029
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:1543-6616
  • Accession Number:164332615
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