JOURNAL ARTICLE

Enterovirus and Parechovirus Neurologic Infections in Children: Clinical Presentations and Neuropathogenesis.

  • Published In: Journal of the Pediatric Infectious Diseases Society, 2025, v. 14, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Freeman, Megan Culler; Messacar, Kevin 3 of 3

Abstract

This article focuses on the epidemiology, clinical presentations, and neuropathogenesis of enteroviruses (EVs) and parechoviruses (PeVs), common childhood pathogens in the picornavirus family that can cause a range of illnesses from mild symptoms to severe neurologic diseases such as meningitis, encephalitis, and acute flaccid myelitis (AFM). Poliovirus, a well-studied EV, causes paralytic poliomyelitis, while nonpolio EVs like EV-D68 have been linked to AFM outbreaks primarily affecting children. PeVs, particularly PeV type 3, are notable causes of severe disease in infants, including sepsis and meningitis. Currently, no approved targeted antiviral therapies exist for these viruses, though vaccines have been successful for poliovirus and EV-A71 in certain regions; ongoing research aims to better understand viral mechanisms and develop effective treatments and preventive measures.

Additional Information

  • Source:Journal of the Pediatric Infectious Diseases Society. 2025/01, Vol. 14, Issue 1, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:2048-7193
  • DOI:10.1093/jpids/piae069
  • Accession Number:182904513
  • Copyright Statement:Copyright of Journal of the Pediatric Infectious Diseases Society is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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