JOURNAL ARTICLE

The antiherpetic and anti-inflammatory activity of the frog-derived peptide Hylin-a1.

  • Published In: Journal of Applied Microbiology, 2024, v. 135, n. 7. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Chianese, Annalisa; Giugliano, Rosa; Palma, Francesca; Nastri, Bianca M; Monti, Alessandra; Doti, Nunzianna; Zannella, Carla; Galdiero, Massimiliano; De Filippis, Anna 3 of 3

Abstract

This article focuses on evaluating the antiviral potential of Hylin-a1, an antiviral peptide (AVP) secreted by the frog *Hypsiboas albopunctatus*, against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). The study demonstrates that Hylin-a1 inhibits early stages of HSV infection by targeting and disrupting the viral envelope, including strains resistant to the standard antiviral drug acyclovir. Additionally, Hylin-a1 exhibits low toxicity to human cells, high stability in serum, anti-inflammatory effects, and synergistic antiviral activity when combined with acyclovir. These findings suggest that Hylin-a1 is a promising candidate for developing new broad-spectrum antiherpetic therapies, warranting further in vivo investigation.

Additional Information

  • Source:Journal of Applied Microbiology. 2024/07, Vol. 135, Issue 7, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1364-5072
  • DOI:10.1093/jambio/lxae165
  • Accession Number:178955479
  • Copyright Statement:Copyright of Journal of Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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