JOURNAL ARTICLE

Botulinum toxin injection of the lower esophageal sphincter to identify achalasia-variant esophagogastric junction outflow obstruction.

  • Published In: Diseases of the Esophagus, 2025, v. 38, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Reddy, Chanakyaram A; Ellison, Ashton; Nguyen, Anh D; Podgaetz, Eitan; Souza, Rhonda F; Konda, Vani J A; Spechler, Stuart J 3 of 3

Abstract

This article focuses on the use of botulinum toxin (BT) injection of the lower esophageal sphincter (LES) as a diagnostic tool to differentiate achalasia-variant esophagogastric junction outflow obstruction (EGJOO) from mechanically-induced EGJOO. In a retrospective study of 13 symptomatic EGJOO patients, a good symptomatic response to BT injection correlated with favorable outcomes following subsequent LES muscle-directed invasive therapies such as pneumatic dilation, Heller myotomy, or per-oral endoscopic myotomy (POEM). Conversely, poor response to BT predicted poor outcomes after invasive treatment. These findings suggest that BT injection can help identify patients with neuromuscular LES dysfunction who are likely to benefit from invasive LES-directed therapies, thereby guiding clinical management of EGJOO.

Additional Information

  • Source:Diseases of the Esophagus. 2025/02, Vol. 38, Issue 1, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1120-8694
  • DOI:10.1093/dote/doae082
  • Accession Number:183431104
  • Copyright Statement:Copyright of Diseases of the Esophagus is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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