JOURNAL ARTICLE

Risk of bleeding with concomitant use of oral anticoagulants and aspirin: A systematic review and meta-analysis.

  • Published In: American Journal of Health-System Pharmacy, 2024, v. 81, n. 12. P. 494 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ghule, Priyanka; Panic, Jennifer; Malone, Daniel C. 3 of 3

Abstract

This article systematically reviews and meta-analyzes the risk of bleeding associated with concurrent use of oral anticoagulants (OACs) and aspirin compared to OAC or aspirin alone. Based on 42 studies including randomized controlled trials (RCTs) and observational studies, the combination of OAC plus aspirin significantly increases the odds of any bleeding event relative to OAC monotherapy (OR ~1.36–1.42) and aspirin monotherapy (OR ~2.36 in RCTs). The majority of included studies involved warfarin as the OAC, with limited data on direct oral anticoagulants (DOACs). Current clinical guidelines generally recommend avoiding long-term concomitant use of OAC and aspirin due to the additive bleeding risk, except in specific high-risk scenarios where benefits may outweigh harms.

Additional Information

  • Source:American Journal of Health-System Pharmacy. 2024/06, Vol. 81, Issue 12, p494
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1079-2082
  • DOI:10.1093/ajhp/zxae010
  • Accession Number:177815805
  • Copyright Statement:Copyright of American Journal of Health-System Pharmacy is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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