JOURNAL ARTICLE

Brachyury Expression in Atypical Teratoid/Rhabdoid Tumor.

  • Published In: International Journal of Surgical Pathology, 2025, v. 33, n. 4. P. 842 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Terzioğlu, Havva Gökçe; Uzun, Sarp; Hench, Juergen; Babaoğlu, Berrin; Matter, Matthias; Söylemezoğlu, Figen; Kösemehmetoğlu, Kemal 3 of 3

Abstract

This article focuses on the expression of brachyury, a T-box transcription factor, in atypical teratoid/rhabdoid tumor (AT/RT), a rare and aggressive pediatric central nervous system tumor characterized by alterations in the SWI/SNF complex such as SMARCB1/INI1 loss. In a study of 44 AT/RT samples from 40 patients, brachyury expression was absent in all but two infratentorial tumors involving the clivus in children under two years old; these two cases were reclassified as poorly differentiated chordoma based on brachyury positivity, morphology, location, and DNA methylation profiling. The findings highlight the diagnostic challenge in distinguishing poorly differentiated chordoma from AT/RT, especially in infratentorial locations, and suggest that brachyury immunohistochemistry, combined with clinical, radiological, and molecular data, can aid in accurate diagnosis.

Additional Information

  • Source:International Journal of Surgical Pathology. 2025/06, Vol. 33, Issue 4, p842
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1066-8969
  • DOI:10.1177/10668969241291896
  • Accession Number:185098269
  • Copyright Statement:Copyright of International Journal of Surgical Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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