JOURNAL ARTICLE

Purification of proanthocyanidins from nut seeds and study on its bactericidal mechanism against Streptococcus mutans.

  • Published In: Journal of Applied Microbiology, 2024, v. 135, n. 9. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lou, Zaixiang; Fan, Xiaoyuan; Liu, Caihua; Liao, Yuemei; Du, Xiaojing; Wang, Hongxin 3 of 3

Abstract

This article focuses on the purification of proanthocyanidins from areca nut seeds (P-AN) and their bactericidal effects against Streptococcus mutans, a primary pathogen involved in dental caries. The study identified P-AN as mainly composed of B-type proanthocyanidins with a degree of polymerization of 13 and demonstrated that P-AN exhibits strong bactericidal activity by disrupting the cell membrane integrity, fluidity, permeability, and membrane proteins of S. mutans. Additionally, P-AN significantly inhibited acid production and biofilm formation by S. mutans, suggesting its potential to reduce tooth surface erosion and prevent dental caries. These findings propose P-AN as a promising natural agent for oral health applications and add value to areca nut seed byproducts.

Additional Information

  • Source:Journal of Applied Microbiology. 2024/09, Vol. 135, Issue 9, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1364-5072
  • DOI:10.1093/jambio/lxae209
  • Accession Number:180046678
  • Copyright Statement:Copyright of Journal of Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.