JOURNAL ARTICLE

P14 Characterizing the hair follicle–nervous system connection.

  • Published In: British Journal of Dermatology, 2024, v. 190, n. 6. P. e85 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Rhodes, Anna; Agramunt, Julià; Limbu, Summik; Laufer, Rimma; Jiménez, Francisco; Williams, Greg; Knight, Leigh; Hashemi, Parastoo; Higgins, Claire 3 of 3

Abstract

This article investigates the influence of the human hair follicle (HF) on the development and maturation of sensory neurons in its surrounding microenvironment. By analyzing single-cell RNA sequencing data and using fast-scan cyclic voltammetry, the study found that specific HF cell types express genes for neurotrophic factors and neurotransmitter production, releasing substances such as serotonin and histamine. These findings suggest that the HF has a greater capacity to signal to the nervous system than interfollicular skin and may play a role in guiding sensory neuron growth. The research highlights a bidirectional relationship between the HF and the nervous system, emphasizing the HF's regulatory role within the skin's sensory microenvironment.

Additional Information

  • Source:British Journal of Dermatology. 2024/06, Vol. 190, Issue 6, pe85
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0007-0963
  • DOI:10.1093/bjd/ljae105.036
  • Accession Number:177358783
  • Copyright Statement:Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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