JOURNAL ARTICLE

GATA3: Everyday Marker Supporting Neuroblastoma, but Pitfall With Rhabdoid Tumors.

  • Published In: International Journal of Surgical Pathology, 2024, v. 32, n. 3. P. 641 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Bobb, Bryce K.; Mochel, Mark C.; Austin, Frances; Smith, Steven C. 3 of 3

Abstract

A letter published in the International Journal of Surgical Pathology discusses the diagnostic utility of the marker GATA3 in differentiating neuroblastoma from other pediatric malignant small round blue cell tumors. The authors highlight the underutilization of GATA3 in supporting the diagnosis of neuroblastoma, despite its routine use as a marker for metastatic carcinoma. They provide a case study where GATA3 expression strongly supported the diagnosis of neuroblastoma in a patient with a renal mass. However, the authors caution that rhabdoid tumors can also show strong GATA3 positivity, which could potentially lead to misdiagnosis. They recommend using a panel of immunostains to differentiate between these entities. [Extracted from the article]

Additional Information

  • Source:International Journal of Surgical Pathology. 2024/05, Vol. 32, Issue 3, p641
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1066-8969
  • DOI:10.1177/10668969231185069
  • Accession Number:176694143
  • Copyright Statement:Copyright of International Journal of Surgical Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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