JOURNAL ARTICLE

Effect of Human Papillomavirus Subtype on the Rate of Positive Surgical Margin After Cervical Conization.

  • Published In: International Journal of Surgical Pathology, 2023, v. 31, n. 1. P. 20 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Purut, Yunus Emre; Giray, Burak; Akis, Serkan; Peker, Esra Keles; Babayeva, Gulchin; Kabaca, Canan; Api, Murat 3 of 3

Abstract

This study investigates whether human papillomavirus (HPV) genotype predicts positive surgical margins following cervical cone excision in women with high-grade cervical intraepithelial neoplasia. Reviewing records of 448 HPV-infected patients treated with loop electrosurgical excision procedure (LEEP) or cold knife conization (CKC), the study found no significant association between HPV subtypes—including HPV 16, HPV 18, and other high-risk HPV (hrHPV) types—and rates of positive surgical margins or endocervical canal involvement. Additionally, margin status was not related to the conization method or the number of excised cervical tissues, though positive margins were more frequent in cases with endocervical canal involvement. These findings suggest that HPV genotype may not be a reliable predictor of positive surgical margins after cervical excisional treatment.

Additional Information

  • Source:International Journal of Surgical Pathology. 2023/02, Vol. 31, Issue 1, p20
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:1066-8969
  • DOI:10.1177/10668969221143460
  • Accession Number:161663846
  • Copyright Statement:Copyright of International Journal of Surgical Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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