JOURNAL ARTICLE

Study of Pharmacokinetics for Ivermectin B1a from Beagle Dogs.

  • Published In: Journal of Chromatographic Science, 2025, v. 63, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Chen, Yuyang; Huang, Xiaofang; Guo, Zizheng; Zhang, Jingyu; Zhang, Lixin; Dai, Renke 3 of 3

Abstract

This article focuses on the development and validation of a liquid chromatograph–mass spectrometer (LC–MS/MS) method for quantifying ivermectin in whole blood samples from beagle dogs to better understand its pharmacokinetic properties. The study found that approximately 32–46% of ivermectin is lost during plasma preparation, supporting the use of whole blood for pharmacokinetic analysis. Oral administration of ivermectin after a high-fat meal or combined with the P-glycoprotein (P-gp) inhibitor curcumin increased ivermectin exposure by about 1.4- to 1.6-fold compared to fasting conditions, suggesting that dietary factors and P-gp inhibition influence ivermectin absorption. These findings provide a pharmacokinetic basis for optimizing ivermectin dosing in future clinical applications, including its antiviral and antibacterial potential.

Additional Information

  • Source:Journal of Chromatographic Science. 2025/03, Vol. 63, Issue 3, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0021-9665
  • DOI:10.1093/chromsci/bmad092
  • Accession Number:184405620
  • Copyright Statement:Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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