Dedicated Breast CT: Getting Ready for Prime Time.

This article focuses on dedicated breast computed tomography (breast CT or bCT), an imaging modality that provides true three-dimensional (3D) imaging of the breast with advantages over conventional breast imaging techniques. Contrast-enhanced breast CT (CEbCT) significantly improves sensitivity and specificity for detecting malignant breast lesions compared to noncontrast bCT and mammography, with potential applications in diagnostic workup, supplemental screening for high-risk women, neoadjuvant chemotherapy response monitoring, and surgical planning. While bCT offers benefits such as short exam times, noncompressed breast positioning, and isotropic 3D imaging, limitations include restricted chest wall and axillary coverage due to prone positioning and the use of ionizing radiation. Current evidence, based on small and heterogeneous studies, suggests CEbCT may complement or partially replace existing imaging modalities, but larger prospective trials are needed to validate its clinical utility and cost-effectiveness.