JOURNAL ARTICLE

Baseline micronucleus frequencies and 60Co cytokinesis-block micronucleus assay dose–response curve for biodosimetry in Vietnam.

  • Published In: Radiation Protection Dosimetry, 2024, v. 200, n. 3. P. 221 1 of 3

  • Database: Applied Science & Technology Source Ultimate 2 of 3

  • Authored By: Pham, Ngoc Duy; Tran, Thanh Mai; Anderson, Donovan; Che, Quang Tuan; Pham, Ho Thuat Khoa 3 of 3

Abstract

This article focuses on establishing baseline micronucleus (MN) frequencies in various Vietnamese populations and developing a gamma cobalt-60 (^60Co) dose–response curve for the cytokinesis-block micronucleus (CBMN) assay to enhance biological dosimetry capabilities. The study measured MN frequencies in healthy donors, male radiation workers, and female breast cancer patients, finding significantly higher baseline MN frequencies in females and breast cancer patients compared to healthy males. The derived dose–response curve, validated through the 2021 RENEB inter-laboratory comparison, supports the CBMN assay as a reliable tool for rapid radiation dose assessment in emergencies, occupational exposure monitoring, and medical contexts in Vietnam. Limitations include a small donor sample for curve construction and variability in baseline MN frequencies influenced by age, sex, and health status, underscoring the need for population-specific reference data in biodosimetry.

Additional Information

  • Source:Radiation Protection Dosimetry. 2024/03, Vol. 200, Issue 3, p221
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:01448420
  • DOI:10.1093/rpd/ncad266
  • Accession Number:176131612
  • Copyright Statement:Copyright of Radiation Protection Dosimetry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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