JOURNAL ARTICLE

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection.

  • Published In: Clinical Infectious Diseases, 2025, v. 80, n. 1. P. 52 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Drekonja, Dimitri M; Shaukat, Aasma; Huang, Yuan; Zhang, Jane H; Reinink, Andrew R; Nugent, Sean; Dominitz, Jason A; Davis-Karim, Anne; Gerding, Dale N; Kyriakides, Tassos C 3 of 3

Abstract

This article reports on the Microbiota or Placebo after Antimicrobial Therapy for Recurrent Clostridioides difficile at Home (MATCH) Study, a randomized, double-blind, placebo-controlled trial conducted within the Veterans Health Administration to evaluate the efficacy and safety of capsule-delivered fecal microbiota transplant (FMT) in preventing recurrent Clostridioides difficile infection (CDI). Among 153 predominantly older male Veterans with recurrent CDI, FMT did not significantly reduce CDI recurrence or death within 56 days compared to placebo. Safety profiles were similar between groups, with no meaningful differences in adverse events. The study highlights that oral FMT, as administered in this trial, was well-tolerated but did not demonstrate clinical benefit in this population under real-world conditions.

Additional Information

  • Source:Clinical Infectious Diseases. 2025/01, Vol. 80, Issue 1, p52
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1058-4838
  • DOI:10.1093/cid/ciae467
  • Accession Number:182798698
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