Bilateral Central Serous Chorioretinopathy in a Patient With XYY Syndrome.

This article focuses on the first reported case of bilateral central serous chorioretinopathy (CSCR) in a 21-year-old male with XYY syndrome, a genetic condition characterized by an extra Y chromosome. CSCR is a common retinopathy typically presenting unilaterally with central vision loss, but bilateral cases in young patients are rare. The patient exhibited subretinal fluid and retinal atrophy in both eyes, alongside thin choroids, which is atypical for CSCR. The authors propose that hormonal dysregulation associated with XYY syndrome, potentially involving elevated endogenous cortisol, may contribute to the development of CSCR in this case, though biochemical confirmation was not obtained. This report expands the understanding of ophthalmologic manifestations in XYY syndrome and suggests a possible link between hormonal factors and bilateral CSCR.