JOURNAL ARTICLE

Comparative study between mitomycin C versus Bacillus Calmette-Guérin (BCG) in high-risk non-muscle-invasive bladder cancer.

  • Published In: Urologia Journal, 2024, v. 91, n. 1. P. 61 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zaza, Mohamed Mahmoud Abdelfatah; Salem, Tarek Abd El-Mageed; El-Sadat, Ahmed Mohamed; Hassan Ali, Mohammed 3 of 3

Abstract

This article focuses on a randomized controlled trial comparing the efficacy and adverse events of Bacillus Calmette-Guérin (BCG) versus Mitomycin C (MMC) in patients with high-risk Non-Muscle-Invasive Bladder Cancer (NMIBC). Conducted over 24 months across four Egyptian hospitals with 90 patients, the study found that both treatments had comparable effectiveness in preventing cancer recurrence and progression. However, the BCG group experienced significantly higher rates of local and systemic adverse reactions, including cystitis, hematuria, fever, and fatigue. The findings suggest that treatment decisions should balance efficacy with side-effect profiles while considering patient preferences and health status, and that further research is needed to confirm these results.

Additional Information

  • Source:Urologia Journal. 2024/02, Vol. 91, Issue 1, p61
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0391-5603
  • DOI:10.1177/03915603231206603
  • Accession Number:176293806
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