Polynucleotides and Hyaluronic Acid (PN-HA) Mixture With or Without Deproteinized Bovine Bone Mineral as a Novel Approach for the Treatment of Deep Infrabony Defects: A Retrospective Case Series.

This article focuses on evaluating the safety and clinical effectiveness of a mixture of polynucleotides and hyaluronic acid (PN-HA), with or without deproteinized bovine bone mineral (DBBM), combined with papillary preservation flaps (PPFs) for treating residual periodontal pockets associated with deep infrabony defects. In a retrospective case series involving 43 patients and 55 defects, treatment with PN-HA, alone or with DBBM in noncontained defects, resulted in significant probing depth reduction (mean 4.4 mm), clinical attachment level gain (mean 3.5 mm), and radiographic bone fill (mean 3.5 mm) after one year, with uneventful healing and minimal gingival recession. Smoking was identified as a negative predictor of clinical outcomes, while no major adverse effects were reported, supporting the safety of PN-HA in periodontal surgery. The authors conclude that PN-HA shows promise as a regenerative agent for infrabony defects, but recommend larger randomized controlled trials to confirm its efficacy compared to established treatments.