JOURNAL ARTICLE

New Findings in Psychological Medicine Described from SRM Institute of Science and Technology (Efficacy of Probiotic Escherichia coli Nissle 1917 in Counteracting Reserpine-induced Depression-like Symptoms and Neuroinflammation in Zebrafish).

Published In: Psychology & Psychiatry Journal, 2026. P. 2971 1 of 2
Database: Psychology Source 2 of 2

Abstract

This article focuses on research from Tamil Nadu, India, investigating the effects of the probiotic Escherichia coli Nissle 1917 (EcN) on depression-like symptoms induced by reserpine in adult zebrafish. Reserpine, an antihypertensive drug known to cause neurotoxicity, was used to induce behavioral deficits, oxidative stress, neuronal damage, and neuroinflammation. Treatment with EcN significantly improved behavioral outcomes, enhanced antioxidant enzyme activities, and reduced pro-inflammatory cytokine levels, showing effects comparable to the antidepressant Venlafaxine. The study suggests EcN as a promising psychobiotic with potential antidepressant-like properties, recommending further research into its mechanisms and clinical applications. [Extracted from the article]

Additional Information

Source:Psychology & Psychiatry Journal. 2026/03, p2971
Document Type:Article
Subject Area:History
Publication Date:2026
ISSN:1944-2718
Accession Number:192110848
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