JOURNAL ARTICLE

Photoredox‐Catalyzed 1,4‐Dichloromethyldimerization of Alkenes with Chloroform: Access to Polychlorinated Vicinal Diaryl Alkanes.

  • Published In: Chemistry - A European Journal, 2025, v. 31, n. 15. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Qian, Zhu‐Ming; Yang, Ming‐Lin; Guan, Zhi; Huang, Chu‐Sheng; He, Yan‐Hong 3 of 3

Abstract

A visible‐light‐mediated strategy is reported for the direct synthesis of polychlorinated vicinal diaryl alkanes from aryl alkenes and chloroform. In this approach, two haloalkyl radicals generated from chloroform via halogen atom transfer (XAT) and direct single electron transfer (SET) within the same photoredox catalysis cycle enable the 1,4‐dichloromethyldimerization of alkenes. Besides chloroform, this strategy is applicable to carbon tetrachloride, bromotrichloromethane, and α‐bromo carboxylic esters, yielding corresponding 1,4‐disubstituted vicinal diaryl alkanes. Diverse polychlorinated structures containing highly congested vicinal quaternary carbon centers are effectively synthesized by this method. The potential of this reaction in late‐stage drug modification is highlighted by the successful transformation of olefins with pharmaceutical structures. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Chemistry - A European Journal. 2025/03, Vol. 31, Issue 15, p1
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2025
  • ISSN:0947-6539
  • DOI:10.1002/chem.202404389
  • Accession Number:183655046
  • Copyright Statement:Copyright of Chemistry - A European Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.