Synergetic Effects of Sericin and Turmeric on Burn Wound Healing in Mice.

The article investigates the synergistic and individual effects of sericin, a protein derived from silkworm cocoons, turmeric, and their nanoparticles on burn wound healing in mice. Female mice with induced burn wounds were treated with sericin, turmeric, sericin + turmeric, sericin nanoparticles, and turmeric nanoparticles, with turmeric nanoparticles (TNPs) showing the most effective results by accelerating wound contraction, enhancing epidermal restoration, and improving histopathological markers such as collagen fibers, keratinocytes, fibroblasts, and blood vessels. Biochemical analyses revealed that TNPs significantly increased antioxidant enzyme levels (glutathione, catalase, glutathione peroxidase, superoxide dismutase) and decreased malondialdehyde, indicating reduced oxidative stress. The study concludes that sericin, turmeric, and their nanoparticles promote burn wound healing, with turmeric nanoparticles demonstrating superior efficacy in this murine model.