The mismatch between Sysmex XN‐20 automated hematology analyzers and the visual examination of blood smears—Misclassification of hypogranular eosinophils and platelets.

The article focuses on the mismatch between automated hematology analyzers and visual examination of blood smears, particularly regarding the misclassification of hypogranular eosinophils and platelets. It reports two cases demonstrating how this mismatch can lead to pseudothrombocytopenia, and it highlights the importance of reviewing peripheral blood smears when abnormal scatterplots or histograms are flagged to avoid diagnostic errors and unnecessary testing.