JOURNAL ARTICLE

Transmission Blocking Activity of Low-dose Tafenoquine in Healthy Volunteers Experimentally Infected With Plasmodium falciparum.

  • Published In: Clinical Infectious Diseases, 2023, v. 76, n. 3. P. 506 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Webster, Rebecca; Mitchell, Hayley; Peters, Jenny M; Heunis, Juanita; O'Neill, Brighid; Gower, Jeremy; Lynch, Sean; Jennings, Helen; Amante, Fiona H; Llewellyn, Stacey; Marquart, Louise; Potter, Adam J; Birrell, Geoffrey W; Edstein, Michael D; Shanks, G Dennis; McCarthy, James S; Barber, Bridget E 3 of 3

Abstract

This article focuses on evaluating the transmission blocking activity of low-dose tafenoquine, an antimalarial drug, against Plasmodium falciparum in healthy volunteers using an induced blood stage malaria (IBSM) model. Six malaria-naïve participants were inoculated with P. falciparum, treated with piperaquine to clear asexual parasites, and then given a single 50 mg oral dose of tafenoquine. Results showed that tafenoquine significantly reduced the proportion of mosquitoes infected with oocysts and sporozoites by days 4 and 7 postdose, despite no significant reduction in gametocyte density, indicating a delayed transmission blocking effect. The study reported no significant safety concerns at this low dose in G6PD-normal individuals, though the small sample size and lack of control group limit the findings.

Additional Information

  • Source:Clinical Infectious Diseases. 2023/02, Vol. 76, Issue 3, p506
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2023
  • ISSN:1058-4838
  • DOI:10.1093/cid/ciac503
  • Accession Number:161829709
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