JOURNAL ARTICLE

What Are Tregs? Explaining 2025's Nobel Prize Winning Research: Regulatory T cells, which prevent the immune system from attacking the body, were the subject of this year's Physiology or Medicine Nobel Prize. How do they work?

  • Published In: Scientist, 2025, v. 39, n. 4. P. 34 1 of 3

  • Database: Agriculture Plus 2 of 3

  • Authored By: MACKENZIE, R. J. 3 of 3

Abstract

The article discusses the 2025 Nobel Prize in Physiology or Medicine awarded for research on regulatory T cells (Tregs), which play a crucial role in preventing the immune system from attacking the body. The prize was given to Shimon Sakaguchi, Fred Ramsdell, and Mary Brunkow for their contributions to identifying and defining Tregs. The article explains the origin and types of Tregs, including thymus-derived Tregs (tTregs), peripheral Tregs (pTregs), and induced Tregs (iTregs), highlighting their mechanisms for suppressing autoimmune responses. Tregs utilize various methods, such as releasing cytokines and consuming interleukin-2, to manage rogue T cells and maintain immune balance. [Extracted from the article]

Additional Information

  • Source:Scientist. 2025/12, Vol. 39, Issue 4, p34
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2025
  • ISSN:0890-3670
  • Accession Number:189446894
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