JOURNAL ARTICLE

Icahn School of Medicine at Mount Sinai Describes Findings in Transcription Factors (Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP-1 Transcription Factor DFOSB).

  • Published In: Mental Health Weekly Digest, 2026. P. 290 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

The article focuses on new research findings regarding DFOSB, a transcription factor involved in various chronic conditions, including drug addiction and cognitive decline. Researchers from the Icahn School of Medicine at Mount Sinai have identified a novel binding site on DFOSB that allows small molecules to modulate its activity, potentially leading to the development of selective inhibitors. One compound, JPC0661, was shown to significantly reduce DFOSB's occupancy at genomic sites, suggesting a new strategy for targeting AP-1 transcription factors. The study highlights the potential for designing small-molecule drugs that can influence the function of DFOSB and related transcription factors. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2026/01, p290
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2026
  • ISSN:1543-6616
  • Accession Number:190627852
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