JOURNAL ARTICLE

Saccharin‐catalyzed multicomponent cascade reactions for the synthesis of 1,2,3,4,6‐pentasubstituted piperidines.

  • Published In: Journal of Heterocyclic Chemistry, 2023, v. 60, n. 6. P. 1070 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Xia, Zihao; Wu, Lisha; Yan, Shiqiang; Zhao, Hanqing 3 of 3

Abstract

A convenient and efficient method is developed for the synthesis of 1,2,3,4,6‐pentasubstituted piperidines via a three‐component, one‐pot domino reaction of β‐ketoesters, aromatic aldehydes, and aromatic amines in the presence of a catalytic amount of saccharin in methanol at 40°C. The desired piperidines could be easily collected through simple filtration with excellent diastereoselectivities. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Journal of Heterocyclic Chemistry. 2023/06, Vol. 60, Issue 6, p1070
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2023
  • ISSN:0022-152X
  • DOI:10.1002/jhet.4628
  • Accession Number:164095513
  • Copyright Statement:Copyright of Journal of Heterocyclic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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