JOURNAL ARTICLE

1,3,4-oxadiazoles with effective anti-mycobacterial activity.

  • Published In: Letters in Applied Microbiology, 2025, v. 78, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Andriato, Patrícia de Mattos; Baldin, Vanessa Pietrowski; de Almeida, Aryadne Larissa; Sampiron, Eloisa Gibin; de Vasconcelos, Sandra Sayuri Nakamura; Caleffi-Fercioli, Katiany Rizzieri; Scodro, Regiane Bertin de Lima; Meneguello, Jean Eduardo; Maigret, Bernard; Kioshima, Érika Seki; Cardoso, Rosilene Fressatti 3 of 3

Abstract

This article focuses on the evaluation of two innovative synthetic 1,3,4-oxadiazole molecules, LMM6 and LMM11, for their antimicrobial activity against Mycobacterium tuberculosis and nontuberculous mycobacteria (NTM). Both compounds demonstrated in vitro activity against M. tuberculosis, including drug-resistant clinical isolates, and showed synergistic or additive effects when combined with classical anti-tuberculosis drugs isoniazid, rifampicin, and ethambutol, without antagonistic interactions. LMM6 and LMM11 exhibited selective toxicity favoring mycobacteria over mammalian HeLa and VERO cells and had limited activity against other bacteria, notably lacking efficacy against Gram-negative species. These findings suggest that LMM6 and LMM11 are promising candidates for further development as antimycobacterial agents targeting TB and NTM infections.

Additional Information

  • Source:Letters in Applied Microbiology. 2025/03, Vol. 78, Issue 3, p1
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2025
  • ISSN:0266-8254
  • DOI:10.1093/lambio/ovaf029
  • Accession Number:184348660
  • Copyright Statement:Copyright of Letters in Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.