JOURNAL ARTICLE

The Ritter reaction of N‐(hydroxymethyl)saccharin with nitriles.

  • Published In: Journal of Heterocyclic Chemistry, 2024, v. 61, n. 1. P. 188 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: de Oliveira, Marllon Nascimento; de Mattos, Marcio C. S. 3 of 3

Abstract

The development of the Ritter reaction of N‐(hydroxymethyl)saccharin with nitriles for the synthesis of N‐[(saccharinyl)methyl]amides is reported. The success of this reaction relies on an operationally simple procedure and on the use of inexpensive reagents. The present method enables access to a variety of saccharin scaffolds of potential interest in medicinal chemistry in moderate to high yields. Furthermore, the scalability of this reaction was demonstrated by a multigram‐scale transformation, without any loss of efficiency. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Journal of Heterocyclic Chemistry. 2024/01, Vol. 61, Issue 1, p188
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2024
  • ISSN:0022-152X
  • DOI:10.1002/jhet.4743
  • Accession Number:174576433
  • Copyright Statement:Copyright of Journal of Heterocyclic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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