JOURNAL ARTICLE

A - 21 The Association between Tau Pathology and Cognitive Impairment in Alzheimer's Disease in the Democratic Republic of Congo.

  • Published In: Archives of Clinical Neuropsychology, 2024, v. 39, n. 7. P. 955 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Thomas, Lexie; Schwinne, Megan; Ikanga, Jean N 3 of 3

Abstract

This article examines the association between phosphorylated tau (p-Tau) pathology and cognitive impairment in older adults with suspected Alzheimer's disease (AD) in the Democratic Republic of Congo (DRC). Using blood biomarkers and neuropsychological tests on 80 Congolese participants, the study classified individuals by ATN profiles based on β-amyloid and p-Tau181 levels, controlling for age, education, gender, and APOEε4 status. Results indicated that higher p-Tau levels correlated with reduced verbal and visual memory performance, supporting the role of tau accumulation in cognitive decline in this population. The findings suggest that p-Tau could serve as an early biomarker for AD pathology in Sub-Saharan African populations.

Additional Information

  • Source:Archives of Clinical Neuropsychology. 2024/10, Vol. 39, Issue 7, p955
  • Document Type:Article
  • Subject Area:History
  • Publication Date:2024
  • ISSN:0887-6177
  • DOI:10.1093/arclin/acae067.035
  • Accession Number:184163326
  • Copyright Statement:Copyright of Archives of Clinical Neuropsychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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