JOURNAL ARTICLE

Management of severe BK viremia in a patient receiving a kidney transplant from a hepatitis C virus–positive donor: A case report.

  • Published In: American Journal of Health-System Pharmacy, 2024, v. 81, n. 2. P. 56 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Gray, Megan; Borges, Leanna; Conrath, Meagan; Marti, Kristen 3 of 3

Abstract

This article focuses on a case of BK virus–related nephropathy leading to kidney allograft failure in a hepatitis C virus (HCV)–negative recipient who received a kidney transplant from an HCV-positive donor. The patient experienced delayed initiation of direct-acting antiviral (DAA) therapy for HCV, which coincided with the development of severe BK viremia and other opportunistic viral infections despite immunosuppression adjustments and intravenous immune globulin treatment. The report highlights emerging evidence that delayed HCV treatment in HCV-discordant transplantation may increase the risk of viral complications, including BK virus nephropathy, and underscores the importance of timely antiviral therapy initiation to improve outcomes. Further research is recommended to clarify the optimal timing of HCV treatment post-transplantation.

Additional Information

  • Source:American Journal of Health-System Pharmacy. 2024/01, Vol. 81, Issue 2, p56
  • Document Type:Article
  • Subject Area:Life Sciences
  • Publication Date:2024
  • ISSN:1079-2082
  • DOI:10.1093/ajhp/zxad250
  • Accession Number:174642893
  • Copyright Statement:Copyright of American Journal of Health-System Pharmacy is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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