JOURNAL ARTICLE

Effect of ursodeoxycholic acid on preventing SARS-CoV-2 infection in patients with liver transplantation: a multicenter retrospective cohort study.

  • Published In: QJM: An International Journal of Medicine, 2024, v. 117, n. 5. P. 339 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Hu, L.; Zhang, H; Huang, C; Shen, T; Feng, Z; Mu, F; Xu, L.; Lin, Y.; Yue, C; Guo, K; Tian, M; Shi, J; Zhang, C; Wen, P; Cao, S; Wang, Y.; Zhang, J.; Shi, X; Wang, Z.; He, Y. 3 of 3

Abstract

This article focuses on assessing the effect of ursodeoxycholic acid (UDCA) on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adult liver transplant (LT) recipients in China from January 2022 to January 2023. In a multicenter retrospective cohort study of 897 LT patients, UDCA treatment was associated with a significantly lower SARS-CoV-2 infection rate compared to non-UDCA treatment (74.1% vs. 84.6%), with a dose-dependent effect observed at doses above 15 mg/kg/day reducing infection rates further to 62.1%. However, UDCA use did not significantly affect the severity of COVID-19 illness, intensive care unit admission, ventilation rates, or hospital stay length. The study suggests UDCA may serve as a host-targeted prophylactic agent against SARS-CoV-2 infection in immunosuppressed LT recipients, though randomized controlled trials are needed to confirm these findings.

Additional Information

  • Source:QJM: An International Journal of Medicine. 2024/05, Vol. 117, Issue 5, p339
  • Document Type:Article
  • Subject Area:Life Sciences
  • Publication Date:2024
  • ISSN:1460-2725
  • DOI:10.1093/qjmed/hcad254
  • Accession Number:177681025
  • Copyright Statement:Copyright of QJM: An International Journal of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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