JOURNAL ARTICLE

Lack of sufficient evidence to support a positive role of selenium status in depression: a systematic review.

  • Published In: Nutrition Reviews, 2025, v. 83, n. 2. P. e211 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Santos, Acsa C; Passos, Anna F F; Holzbach, Luciana C; Cardoso, Barbara R; Santos, Marta A; Coelho, Alexandre S G; Cominetti, Cristiane; Almeida, Gessica M 3 of 3

Abstract

This systematic review evaluates the impact of selenium intake and status on depression symptoms in adults aged 18–60 years by analyzing 10 studies, including cohorts, cross-sectional studies, case-control studies, and randomized controlled trials from multiple countries. While several studies suggest that low selenium intake or concentration may be associated with increased depressive symptoms, the evidence is inconsistent due to high heterogeneity in study designs, depression assessment methods, selenium measurement techniques, and participant clinical conditions. The review concludes that current evidence is insufficient to confirm a positive role of selenium in depression, highlighting the need for more rigorous, standardized research to clarify selenium's potential effects on depressive disorders.

Additional Information

  • Source:Nutrition Reviews. 2025/02, Vol. 83, Issue 2, pe211
  • Document Type:Article
  • Subject Area:Nutrition and Dietetics
  • Publication Date:2025
  • ISSN:0029-6643
  • DOI:10.1093/nutrit/nuac095
  • Accession Number:182214660
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