JOURNAL ARTICLE

Isolation of Lactobacillus acidophilus strain and its anti-obesity effect in a diet induced obese murine model.

  • Published In: Letters in Applied Microbiology, 2024, v. 77, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zheng, Yanyi; Zhang, Silu; Zhang, Zhizhu; Zhang, Tengxun; Teng, Xin; Xiao, Guoxun; Huang, Song 3 of 3

Abstract

This article focuses on the isolation and evaluation of a probiotic strain, Lactobacillus acidophilus GOLDGUT-LA100 (LA100), characterized by high bile salt hydrolase (BSH) activity and tolerance to gastric acid and bile salts, for its potential anti-obesity effects. In a high-fat diet-induced obese mouse model, oral administration of LA100 significantly reduced body weight gain, serum glucose and cholesterol levels, hepatic lipid accumulation, and adipose tissue inflammation compared to controls. The study establishes a screening pipeline for probiotics with high BSH activity and suggests that LA100 may mitigate obesity-associated metabolic disorders, supporting further clinical investigation.

Additional Information

  • Source:Letters in Applied Microbiology. 2024/03, Vol. 77, Issue 3, p1
  • Document Type:Article
  • Subject Area:Nutrition and Dietetics
  • Publication Date:2024
  • ISSN:0266-8254
  • DOI:10.1093/lambio/ovae021
  • Accession Number:176342084
  • Copyright Statement:Copyright of Letters in Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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