JOURNAL ARTICLE

A single administration of barley β-glucan and arabinoxylan extracts reduces blood glucose levels at the second meal via intestinal fermentation.

  • Published In: Bioscience, Biotechnology & Biochemistry, 2023, v. 87, n. 1. P. 99 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Kento Mio; Togo-Ohno, Marina; Natsuki Tadenuma; Reina Ogawa; Chiemi Yamanaka; Seiichiro Aoe 3 of 3

Abstract

This article investigates the "second meal effect" of barley-derived soluble fibers—β-glucan and arabinoxylan—on blood glucose regulation in mice. The study demonstrates that a single administration of these fibers suppresses blood glucose elevation at a subsequent meal, likely through intestinal fermentation that produces short-chain fatty acids (SCFAs), which in turn stimulate glucagon-like peptide-1 (GLP-1) secretion. β-glucan primarily affected the first meal by increasing intestinal viscosity, while both β-glucan and arabinoxylan influenced the second meal via different fermentation sites in the gut, reflected by distinct SCFA profiles and gene expression related to L-cell function. These findings suggest that barley soluble fibers may contribute to improved glycemic control through mechanisms involving gut fermentation and hormone regulation.

Additional Information

  • Source:Bioscience, Biotechnology & Biochemistry. 2023/01, Vol. 87, Issue 1, p99
  • Document Type:Article
  • Subject Area:Nutrition and Dietetics
  • Publication Date:2023
  • ISSN:0916-8451
  • DOI:10.1093/bbb/zbac171
  • Accession Number:161134564
  • Copyright Statement:Copyright of Bioscience, Biotechnology & Biochemistry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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