JOURNAL ARTICLE

Modulation of pulmonary oxidative status in methamphetamine-withdrawn rats, comparing the effects of continuous training and NBS superfood supplementation.

  • Published In: Clinical Hemorheology & Microcirculation, 2024, v. 88, n. 3. P. 373 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Saydi, Ali; Behpoor, Naser; Khamis Abadi, Fatemeh; Jung, Friedrich; Kordi, Negin 3 of 3

Abstract

This study investigated the effects of six weeks of continuous treadmill training and Nutrition Bio-Shield (NBS) Superfood supplementation—a wheat germ-based herbal product—on oxidative stress markers in the lungs of rats following methamphetamine (METH) withdrawal. Results showed that both interventions, alone or combined, significantly increased the expression of the antioxidant-related gene Nrf2 while reducing the expression of oxidative stress-related genes NOX4, malondialdehyde (MDA), and superoxide dismutase (SOD) compared to controls. These findings suggest that continuous exercise and NBS supplementation may mitigate METH-induced pulmonary oxidative damage by modulating gene expression linked to antioxidant defense. The study highlights the potential of natural supplements and physical activity in addressing oxidative stress during METH withdrawal, though further research is recommended to explore related signaling pathways and protein-level effects.

Additional Information

  • Source:Clinical Hemorheology & Microcirculation. 2024/10, Vol. 88, Issue 3, p373
  • Document Type:Article
  • Subject Area:Nutrition and Dietetics
  • Publication Date:2024
  • ISSN:1386-0291
  • DOI:10.3233/CH-242306
  • Accession Number:181484173
  • Copyright Statement:Copyright of Clinical Hemorheology & Microcirculation is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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