JOURNAL ARTICLE

Significance of understanding the genomics of host–pathogen interaction in limiting antibiotic resistance development: lessons from COVID-19 pandemic.

  • Published In: Briefings in Functional Genomics, 2024, v. 23, n. 1. P. 69 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Yadav, Vikas; Ravichandran, Srividhya 3 of 3

Abstract

The article focuses on the impact of the COVID-19 pandemic on antimicrobial resistance (AMR) and explores how genomics-based understanding of host–pathogen interactions can help mitigate the misuse of antibiotics that contributes to AMR. It reviews genetic variations in both the human host and SARS-CoV-2 virus that influence infection susceptibility and treatment efficacy, highlighting that antibiotics have limited antiviral effectiveness and should be used judiciously, primarily to manage bacterial co-infections rather than as monotherapy for viral infections. The article emphasizes the need for strengthened antibiotic stewardship programs globally to prevent an AMR-driven pandemic and suggests that genomic surveillance can guide more precise therapeutic strategies in future pandemics.

Additional Information

  • Source:Briefings in Functional Genomics. 2024/01, Vol. 23, Issue 1, p69
  • Document Type:Article
  • Subject Area:Pharmacy and Pharmacology
  • Publication Date:2024
  • ISSN:2041-2649
  • DOI:10.1093/bfgp/elad001
  • Accession Number:174909803
  • Copyright Statement:Copyright of Briefings in Functional Genomics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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