JOURNAL ARTICLE

Optimization of oral isavuconazole dose for population in special physiological or pathological state: a physiologically based pharmacokinetics model-informed precision dosing.

  • Published In: Journal of Antimicrobial Chemotherapy (JAC), 2024, v. 79, n. 9. P. 2379 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zhou, Jianxing; Xu, Baohua; Zheng, You; Huang, Huiping; Wei, Zipeng; Chen, Shengyang; Huang, Wei; Liu, Maobai; Zhang, Yifan; Wu, Xuemei 3 of 3

Abstract

This article focuses on the development and validation of a physiologically based pharmacokinetic (PBPK) model for oral isavuconazole (ISA), a broad-spectrum antifungal drug, to optimize dosing regimens across special populations. Using data from 25 clinical pharmacokinetic studies, the model accurately predicted ISA disposition in healthy volunteers and populations with severe hepatic impairment (HI), obesity, and pediatric patients aged 1 to less than 6 years. The study recommends halving the maintenance dose for patients with severe HI while increasing the loading dose to 300 mg every 8 hours for both HI and obese populations, and suggests a weight-based dosing regimen of 5.38 mg/kg for young pediatric patients. These dosing adjustments aim to improve therapeutic efficacy and precision dosing in populations with altered physiological or pathological states.

Additional Information

  • Source:Journal of Antimicrobial Chemotherapy (JAC). 2024/09, Vol. 79, Issue 9, p2379
  • Document Type:Article
  • Subject Area:Pharmacy and Pharmacology
  • Publication Date:2024
  • ISSN:0305-7453
  • DOI:10.1093/jac/dkae240
  • Accession Number:179421979
  • Copyright Statement:Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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