A mobile APP-based, customizable automated device for self-administered olfactory testing and an implementation of smell identification test.

This article focuses on the development and validation of a mobile Digital Olfactory Testing System (DOTS) designed for psychophysical and clinical assessment of human smell identification ability. DOTS comprises a portable odor delivery device (DOTS-ODD) and a customizable mobile application (DOTS-APP) that wirelessly controls odor presentation and records detailed response data. Implementing a 40-item smell identification test based on the University of Pennsylvania Smell Identification Test (UPSIT), DOTS was validated against UPSIT in cohorts of 80 normosmic individuals and 12 Parkinson's disease patients, showing a strong correlation (r = 0.714, P < 0.001) and high test–retest reliability (r = 0.807, P < 0.001). The system's portability, programmability, and cultural adaptability address limitations of manual olfactory tests, supporting its potential for large-scale, remote, and longitudinal olfactory research and clinical screening.