Development of an affine transformation based treatment control system for accelerator based boron neutron capture therapy.

This article focuses on the development and validation of an adaptive Treatment Control System (TCS) based on affine transformation for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), a targeted radiotherapy technique using boron-10 and neutron irradiation to selectively destroy tumor cells. The system integrates real-time stereoscopic x-ray imaging and a six-axis robotic treatment bed to achieve high-precision patient positioning and dynamic treatment plan adjustments, enhancing dose accuracy and minimizing damage to healthy tissues. The TCS employs hardware-based safety interlocks independent of software control and a browser/server software architecture for flexible, centralized device management. Extensive positioning tests—including translational, rotational, rigidity, phantom, and anthropomorphic phantom evaluations—demonstrated the system’s high accuracy and stability, surpassing international recommendations for radiotherapy positioning. The study concludes that this adaptive TCS shows promise for improving AB-BNCT treatment precision and safety, with potential for broader clinical applications in cancer therapy.