JOURNAL ARTICLE

It takes two: intranasal trigeminal chemosensation and its role in odor processing.

  • Published In: Chemical Senses, 2025, v. 50. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Migneault-Bouchard, Chloé; MARTIN, CLAIRE; Frasnelli, Johannes; Genovese, Federica 3 of 3

Abstract

The article focuses on the role of the trigeminal system in nasal chemosensation and its interaction with the olfactory system in shaping odor perception. It reviews the molecular and physiological mechanisms underlying trigeminal chemosensation, emphasizing the function of transient receptor potential (TRP) channels—specifically TRPA1, TRPV1, TRPM8, and TRPV3—in detecting chemical and thermal stimuli. The trigeminal and olfactory systems, though distinct, converge anatomically and functionally at multiple levels, including the olfactory epithelium, olfactory bulb, and brain regions, resulting in complex multisensory integration that modulates perception. The article also discusses methodological approaches for studying trigeminal function in humans and animal models, the impact of trigeminal dysfunction in olfactory disorders and Parkinson's disease, and the trigeminal system's contribution to subjective nasal sensations. Overall, it highlights the importance of the trigeminal system in chemosensory perception and calls for further research to elucidate its roles in health and disease.

Additional Information

  • Source:Chemical Senses. 2025/01, Vol. 50, p1
  • Document Type:Article
  • Subject Area:Psychology
  • Publication Date:2025
  • ISSN:0379-864X
  • DOI:10.1093/chemse/bjaf056
  • Accession Number:192513346
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