JOURNAL ARTICLE

A - 21 Sex Differences in Cortical Thickness and Cognition in Individuals with Autosomal Dominant Alzheimer's Disease.

  • Published In: Archives of Clinical Neuropsychology, 2023, v. 38, n. 7. P. 1183 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Giudicessi, Averi; Fox-Fuller, Joshua T; Chen, Yinghua; Su, Yi; Banea, Ana; Martinez, Jairo E; Pluim, Celina; Angella, Stephanie; Cronin-Golomb, Alice; Castelar, Clara Vila; Restrepo, Francisco Lopera; Quiroz, Yakeel T 3 of 3

Abstract

This article focuses on sex differences in cortical thickness and cognitive performance among individuals with autosomal dominant Alzheimer's disease (ADAD), a genetic form of early-onset dementia. The study assessed 85 carriers of the Presenilin-1 E280A mutation, measuring global cognition and memory alongside brain MRI to evaluate cortical thickness. Results showed no overall sex differences in cortical thickness or cognition, but greater cortical thickness correlated with better cognitive scores primarily in female carriers, while this association was not significant in males. Notably, among cognitively unimpaired female carriers, increased cortical thickness was linked to worse cognitive performance. These findings suggest sex-specific relationships between brain structure and cognition in ADAD, warranting further investigation into underlying mechanisms.

Additional Information

  • Source:Archives of Clinical Neuropsychology. 2023/10, Vol. 38, Issue 7, p1183
  • Document Type:Abstract
  • Subject Area:Psychology
  • Publication Date:2023
  • ISSN:0887-6177
  • DOI:10.1093/arclin/acad067.039
  • Accession Number:174274817
  • Copyright Statement:Copyright of Archives of Clinical Neuropsychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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